The Avalanche didn't take another penalty for the rest of the game, but the damage had already been done as it ended up being shutout 2-0 after Evander Kane sealed the game with another tally with 4:14 left to play.
"We came out and had a great first couple shifts," said Colorado captain Gabriel Landeskog. "We get a couple penalties called against us. They're the first power play in the league for a reason, and you see that. They're extremely hard to stop and they move it around, and you give them enough chances, they're eventually going to score."
Buffalo actually entered the game second in the NHL on the power play with a 23.1 percent success rate and got energy from its two early man advantages as it outshot Colorado 10-2 in the final 17 minutes of the period.
"We take two unnecessary, needless penalties up ice when guys are outstaying us and we're reaching," said head coach Jared Bednar. "Those power plays gave them momentum, and they shoot the puck and their power play is dangerous at home."
The Sabres controlled play in the middle frame but were only up 1-0 at the intermission. The Avalanche had a much better third period and had chances to tie the contest.
"It was a one-goal hockey game," Landeskog said. "We just wanted to push and make plays and be desperate, and I think we did. We ended up falling short."