Kyle Palmieri redirected a feed from Taylor Hall past Hutton to get the Devils on the board only 37 seconds into the second period. Palmieri's blast came from the hashmarks.
Two minutes later, Kyle Okposo's wrist shot from the point found its way through multiple screens past Blackwood to give the Sabres back their two-goal lead.
Blackwood made an excellent stop off Eichel on the breakaway near the midway point of the second but a minute later, Skinner wired a shot high off the rush to make it 4-1 Buffalo.
With Coleman in the box for tripping, the Sabres struck for their third power play goal of the night with 6:27 to go in the period. Olofsson's shot from the right circle was blocked but the puck found its way back to him and he then blasted it by Blackwood to make it 5-1.
A minute after that goal, Hall was hit hard into the boards by Jake McCabe. Moments later, Simmonds dropped the gloves with the Sabres defenseman. Simmonds ended up with four minutes for roughing while McCabe got two for roughing. Result was another Sabres power play. Subban and Simmonds each got 10-minute misconducts as well.
After two, shots on goal were 12-5 for the Devils.