But Matthews had the final say on this night.
The game went to overtime thanks to Marleau's tying goal at 14:37 of the third period. Matthews followed with the winner on a wrist shot that whizzed past Sabres goalie Linus Ullmark with 2.7 seconds remaining.
As Matthews pumped his fist and unleashed a scream, Eichel's head slumped in disappointment. Each should hold his head high.
"I think, in the end, you kind of treat it as another game, but when you go against superstars on the other side like himself, I think it elevates your game a bit," Matthews said of facing Eichel. "We knew going into it, it was going to be a tight game. They've been playing extremely well lately, and it definitely went back and forth there. We're happy to walk out of here with two points."
Eichel was understandably down after the loss.
"I thought we played a great game tonight," he said. "Obviously, they get the extra point and it's frustrating, but give us credit … I thought we brought a lot of compete and effort."
The Edmonton Oilers selected Connor McDavid No. 1 in the 2015 NHL Draft, leaving the Sabres to take Eichel at No. 2. But any McDavid-Eichel rivalry is tempered by the fact that the two play in different conferences, meaning they play against each other twice a season. Their only Stanley Cup Playoff matchup would come in the Final. The same dynamic applies to Matthews, the No. 1 pick in the 2016 NHL Draft, and Winnipeg Jets forward Patrick Laine, who was taken at No. 2.
The Sabres and Maple Leafs play each other four times in the regular season and could meet in the first or second round of the playoffs because they are in the same division.
"Playoffs are where rivalries heat up," Marleau said. "That's what happened with Sid and Ovie."
Local talk shows in each city were buzzing on Wednesday over the performances of Matthews and Eichel. The common question asked of listeners: Which head-to-head matchup of NHL greats does Matthews-Eichel have the chance to replicate?
Early returns indicate the obvious choice is Crosby-Ovechkin. Matthews and Eichel haven't reached that stage. Yet. But if Tuesday is any indication, they are well on their way.