"I've been a part of a few losing streaks during my career, and they all [stink]," Reimer said. "I thought our sense of urgency was just incredible tonight. It's a comfortable feeling back there when every guy is working that hard."
Christian Fischer, Patrick Kane, Daniel Sprong and Lucas Raymond scored for Detroit (34-27-6), which had been outscored 36-12 during the skid, and hadn't won since an 8-3 victory against the Washington Capitals on Feb. 27.
Detroit moved into the second wild card into the Stanley Cup Playoffs from the Eastern Conference, one point ahead of the New York Islanders, who lost 4-3 to the Ottawa Senators in overtime on Saturday.
"I think we were a little more organized and a little more patient in the neutral zone," Red Wings coach Derek Lalonde said. "That takes away who [the Sabres] are -- all their speed and four guys in the rush."
Tage Thompson scored for Buffalo (32-31-5), which was 8-3-1 in its past 12 games and had won three straight, including 7-3 against Detroit on Tuesday. Ukko-Pekka Luukkonen made 22 saves for the Sabres, who fell five points behind the Red Wings.
"That was two desperate teams going at it," Thompson said. "We're on their heels."
Thompson gave Buffalo a 1-0 lead with a power-play goal at 11:22 of the first period.
Fischer tied it 1-1 at 5:35 of the second period, pushing the puck past Luukkonen while sliding on his side. It was his first goal in 42 games.
"That's just how I meant to do it," Fischer joked. "That's just being a bad skater -- I don't even think anyone tripped me."