The forward, traded to the Sabres by the Hurricanes for forward Cliff Pu and three draft picks on Aug. 2, has three goals in his past three games and 42 points (29 goals, 13 assists) in 43 games for Buffalo, 3-5-1 in its past nine games.
Skinner played the first eight seasons of his NHL career with Carolina and scored at least 20 goals six times, including an NHL career-high 37 in 2016-17. He won the Calder Trophy as NHL rookie of the year in 2010-11.
Sabres center Jack Eichel will return after missing three games with an upper-body injury.
The Hurricanes will try to win for the sixth time in seven games; they're 5-1-0 in their past six and have scored at least four goals in four of their past five.