Buffalo reconfigured its forward lines in practice Friday after scoring one goal in three games of its previous four.
Skinner and Pominville were moved to the first line with Eichel, and the impact was evident from the start, with Pominville giving the Sabres a 1-0 lead at 10:24 of the first period. Los Angeles used a coach's challenge for goaltender interference, but the call on the ice was upheld.
Skinner scored twice in the second period, at 3:31 to give Buffalo a 2-0 lead and at 15:52 for a 3-0 lead.
"The key was generating some offensive-zone time I think," Skinner said. "Both my goals sort of came off the cycle, and I think [Jason's] goal off the rush, but again, it's being hard at the net."
Zach Bogosian scored his first of the season to make it 4-0 at 19:45 of the second.