Sabres goalie Carter Hutton made two saves before a lower-body injury forced him out of the game at 2:53 of the first period. Dustin Tokarski relieved Hutton and made 33 saves in his first NHL game since Oct. 28, 2016, with the Anaheim Ducks.
"It was a lot of fun," Tokarski said. "It's been a little while. I've had some ups and downs in the last four, five years, but it's been a good few years. I'm excited to be a part of Buffalo and get the opportunity to play in a game."
Chris Kreider scored two goals, including the game-winner on the power play at 5:47 of the third period after the Sabres tied the game 3-3 by scoring on their first two shots of the period.
Adam Fox had a goal and two assists in his 100th NHL game, Artemi Panarin had three assists, and Keith Kinkaid made 16 saves for the Rangers (14-13-4), who are 4-1-1 in their past six games.
"You sometimes get caught up in the standings but they're still a good team, they're an NHL team there, and they have NHL players," Fox said. "For us, it was important to continue our strong play against one of the top teams like [the] Washington [Capitals, a 3-1 win Saturday] and carry that over."
The Rangers played their fourth straight game with Kris Knoblauch, the coach of Hartford, their American Hockey League affiliate, as acting coach. David Quinn and assistants Jacques Martin, David Oliver and Greg Brown remained unavailable in accordance with NHL COVID-19 protocols.
New York is 3-1-0 under Knoblauch.
"They just seem really resilient, and there's nothing fazing them right now," Knoblauch said. "We did have a 3-1 lead. Guys could have been upset and really worried, playing tight, but they didn't. They just continued to play on."