Krueger last coached in the NHL in 2012-13, when the Edmonton Oilers were 19-22-7 during a shortened 48-game regular season. The Sabres were 33-39-10 under coach Phil Housley last season.
Forwards Alex Galchenyuk and Brandon Tanev could debut on the second line for the Penguins. Galchenyuk, acquired in a trade with the Arizona Coyotes on June 29, is a game-time decision with a lower-body injury. He had 41 points (19 goals, 22 assists) in 72 games with the Coyotes last season.
Tanev signed a six-year contract with Pittsburgh on July 1 after having an NHL career-high 29 points (14 goals, 15 assists) in 80 games with the Winnipeg Jets last season.
Pittsburgh is 15-0-3 in its past 18 games against Buffalo and 8-0-1 in its past nine home games against the Sabres.