"I think you guys knew, we knew, everyone knew that this was the biggest game of the year, right?" Domi said. "We had to come off a few tough losses and we managed to do that, so that one's out of the way and now we've just go to focus on the next one."
Byron, who played 13:36 in his 400th NHL game after missing the past six because of an arm injury, made it 2-0 at 17:12.
Anderson made it 2-1 at 1:05 of the second on a wrist shot inside the right post from the right face-off dot on a 2-on-1.
"It's disappointing," Foligno said. "We played, especially in the second half, I just thought our defensive mindset was so much better, which created our offensive output. You know, you could see us getting more chances because of it and it's disappointing to not come away with at least a point in that game."
Forward Artemi Panarin (illness) did not play for Columbus, which was also without defenseman Ryan Murray, who sustained an upper-body injury in a 5-1 loss to the Tampa Bay Lightning on Monday. Panarin leads the Blue Jackets with 67 points (24 goals, 43 assists).