Granato and Ellis were not available for a 4-0 loss at the Pittsburgh Penguins on Thursday after entering protocol earlier in the day and then missing practice Friday.
Linus Ullmark also returned for the Sabres on Saturday. The goalie had not played since sustaining a lower-body injury in a 4-3 overtime loss to the New Jersey Devils on Feb. 25.
The Sabres (6-23-4) had their game against the Bruins last Saturday postponed due to protocol. They also had six games postponed and their facilities closed from Feb. 2-13, and had nine players on the protocol list during that span.
"Obviously, we've experienced it a few times now with positive cases," defenseman Brandon Montour said. "Obviously those newer faces on the bench, newer roles, with Donnie we're all hoping for the best news for his sake and his health. ... All we're thinking about is the health of them and hopefully they're safe. We're glad everything's on track with that and we'll see them soon.
"Like I said, we've experienced it a few times already. It's a weird year for every team, everybody in the world. Just got to go with the punches and go each day, each time you step on the ice or practice, it's the way it is this year. Whoever's behind the bench or whoever's playing, it's the next man up and that's the best thing you can do right now."
General manager Kevyn Adams coached the Sabres on Thursday.
"There's a different perspective when you're behind the bench," Adams said. "You're feeling the emotions of the game. You're understanding how the players are interacting. You just see things in a little bit of a different way at ice level. So for sure, for me, I learned. [The] downside to that was it was challenging circumstances around."
Adams said Granato and Adams had no symptoms and were "both feeling great. They're both doing good."
The Sabres have lost 17 straight games, extending the NHL record for the shootout era (since 2005-06). Buffalo is 0-5-0 and has been outscored 21-9 since Ralph Krueger was fired as coach March 17.
"You're ready for anything at this point in time," forward Taylor Hall said. "You have to be on your heels. Never know what to expect. We adjust. We were able to have a meeting with all of them beforehand in the morning, so kind of knew what the game plan was and the summation of last game was. So we just went out and played and tried as hard as we could."
Buffalo is 0-15-2 since Feb. 25, the longest stretch without a win since the NHL implemented the shootout, eliminating ties. The 2009-10 Carolina Hurricanes, 2010-11 New York Islanders and 2014-15 Sabres each lost 14 consecutive games. The Winnipeg Jets hold the NHL record for most consecutive games without a win; they played 30 straight without a victory (0-23 with seven ties) from Oct. 19-Dec. 20, 1980.
The New Jersey Devils are the only team the Sabres have defeated since Jan. 28. They are 3-2-1 against the Devils and 0-18-2 against the rest of the MassMutual East Division in that span.
Adams was an assistant under Lindy Ruff with the Sabres from 2011-13. He was a development coach with Buffalo from 2009-11.
Asked about his level of comfort coaching on short notice, he said, "A lot of the prep work was done previously overnight and into this morning. As you prepare a team, we obviously played them last night (a 5-2 loss), so the prescout's a little different. For me, I'm comfortable. Obviously, I've been watching every game. I've been with the team all season. I know our team extremely well. I know the personnel and tendencies. So obviously, have been behind a bench before. I think the players, also, in these situations know this is an opportunity for them to take on adversity in their own way and be better for it. That was part of the message to, 'Hey, we're all in this together. Let's do the best we can.'"
NHL.com independent correspondents Wes Crosby and Heather Engel contributed to this report
