Pittsburgh (40-26-4) is second in the Metropolitan Division with 84 points, one behind the Washington Capitals and three ahead of the Philadelphia Flyers.
Goalies Casey DeSmith and Tristan Jarry have shared the starting role in the seven games Murray has missed. DeSmith is expected to start for the second straight game after making 17 saves in a 3-1 win against the Dallas Stars on Sunday.
Murray is 23-13-2 with a 2.82 goals-against average and .909 save percentage in 41 games.
Forward Bryan Rust, out since sustaining a concussion March 7, is a game-time decision, Sullivan said.
Rust would play on the third line with Derick Brassard and Phil Kessel against the Rangers.
"I think I can be that energy guy for them," Rust said. "I can go retrieve pucks. I can be hard on D-men. I can dart in and out of space to try and create some lanes, create a little more space for them to do what they do with the puck."
Rust has 33 points (10 goals, 23 assists) in 57 games this season, his fourth in the NHL, and 14 points (six goals, eight assists) in 17 games since the All-Star break.