Pominville received a pass from Seth Griffith and took a backhand shot that beat Price to the stick side for his first goal for Buffalo since March 21, 2013, against the Toronto Maple Leafs. Pominville was re-acquired in a trade from the Minnesota Wild on June 30.
"It's got to be great coming back," Sabres coach Phil Housley said. "Any time you can contribute coming back to your team, or you're a new player on a new team, it's great. You get a lot of confidence and I think especially him coming back, a home reunion. It's good to see him get a couple tonight and, hopefully, there's a lot more to come."
Pacioretty's goal came after Brendan Gallagher picked up a loose puck when Ryan O'Reilly fanned on a pass. Gallagher passed to Drouin, who found Pacioretty open in the face-off circle for a one-timer that beat Lehner, who made 38 saves.
Pominville made it 2-1 22 seconds into the second period.
Philip Danault made it 2-2 with a shorthanded goal at 8:01 of the third. Danault picked up a loose puck behind the net and beat Lehner with a wraparound shot.
"It's a fast play," Lehner said. "I get there with my skate and he goes up on it and it hit my pad and goes in. It happens in a split second and it's frustrating. It's a lucky goal."