The Devils, who look to avoid their sixth straight loss (0-2-3 in their past five games), are third in the Metropolitan Division with 52 points.
Hischier, 19, who became the first Switzerland-born player selected No. 1 in an NHL draft, is tied with forward Jesper Bratt for second on New Jersey in scoring with 26 points (eight goals, 18 assists) behind forward Taylor Hall, who has 42 points (15 goals, 27 assists).
Patrick, 19, has eight points (two goals, six assists) in 33 games for the Flyers, who are seventh in the Metropolitan Division with 46 points and seek their fourth consecutive win. Defenseman Shayne Gostisbehere, who did not practice on Friday and was absent from the morning skate, is not expected to play because of an illness.