Evgeni Malkin scored on a one-timer off a pass from Kris Letang on a 4-on-3 to make it 3-0 at 6:48. On the ensuing face-off, Sidney Crosby knocked the puck between the skates of Flyers captain Claude Giroux and skated into the Philadelphia zone before sending a backhand pass to Brian Dumoulin, who scored five-hole on Flyers goaltender Brian Elliott at 6:53 to extend the lead to 4-0.
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"[Jake Guentzel] poked it forward and then I saw [Dumoulin] coming in late on the rush," Crosby said. "Tried to find him there. I don't know where he shot it, but he made a great read jumping up on the play and giving us numbers there."
Pittsburgh leads the best-of-7 series 2-1. Game 4 is at Philadelphia on Wednesday.
Crosby had a goal and three assists, Malkin had a goal and an assist, and Matt Murray made 26 saves for Pittsburgh.
Crosby has 171 points (61, 110 assists) in the playoffs, one behind Mario Lemieux for first in Penguins history.
"We've got a couple days so it's good to get this one," Crosby said. "Now, we come back having that first one played here, got a feel for it, and that should help us here going into Game 4."
Travis Sanheim scored, and Elliott made 21 saves for Philadelphia.