Alex Tuch scored twice, and Rasmus Dahlin had a goal and an assist for the Sabres (20-17-2), who had won eight of 10.
"I think they capitalized and we didn't, honestly," Tuch said. "I thought we had some momentum for the majority of the game, and when we kind of sat back a little bit got a little frustration, left some spots open in the [defensive] zone, and that's when they capitalized. [We had a] couple turnovers. I thought it was a little bit better than last night (a 4-0 loss to the Philadelphia Flyers), but we have to take a bigger step to beat a team that's been playing really well as of late."
Eric Comrie made 18 saves in his first start since sustaining a lower-body injury Nov. 16.
"It's going to take time," he said. "This is my first game in a long time in the NHL. You're not just stepping into the easiest environment in the world. I mean, you're stepping into the best league in the world. Yeah, I felt fine, but there's still a feeling I wasn't quite all there, if you know what I mean."