Girgensons sustained a lower-body injury during the Sabres' 5-4 overtime loss at the Vegas Golden Knights on Tuesday when he blocked a shot by Golden Knights defenseman Brad Hunt. Gorges is also out with a lower-body injury and did not practice Thursday.
Buffalo will attempt to avoid a 1-5-2 start, which would be its worst since it opened the season 1-7-0 in 2014-15.
Goaltender Chad Johnson will make his third consecutive start for the Sabres. He helped propel Buffalo to its first win of the season on Sunday with 25 saves in a 3-1 victory at the Anaheim Ducks and made 26 saves in the loss to Vegas. Robin Lehner, Buffalo's No. 1 goaltender, missed practice Thursday with an illness but will back up Johnson.
Goaltender Jacob Markstrom will start for the Canucks. He replaced Anders Nilsson in the first period of a 6-3 loss at the Boston Bruins on Thursday, after Nilsson allowed four goals, three on the power play, on 17 shots. Markstrom allowed two goals on 18 shots in 49:01.