The Sabres started out strong, generating quality chances in the Avalanche zone, but it was the Avalanche who struck first. Gabriel Landeskog scored on the power play with 5:36 left in the first. However, the Sabres responded quickly.
Kyle Okposo drove in and threw the puck in front where a crashing Girgensons was able to tip it and tie the game with 3:39 remaining.
Colorado regained the lead at the 7:15 mark of the second period when Martin Kaut put home rebound on the power play for his first NHL goal.
The Avalanche were buzzing after the goal, and the two teams traded chances for the remainder of the period. Sam Reinhart was stopped by a diving Francouz midway through the second and then Hutton made a great save on Valeri Nichushkin
Then with 5:04 left, Lazar evened the score when he tipped in a wrist shot from the point by Jake McCabe.
Then 2:38 into the second period, the Avalanche though the took the lead, but the officials ruled that Tyson Jost had deflected the puck in with a high stick.
However, Colorado would take the lead when J.T. Compher got loose in front and put a Joonas Donskoi shot in past Hutton with 8:06 left in regulation.
Buffalo upped their pressure in the final minute with the extra attacker, but were unable to beat Francouz. Victor Olofsson hit the post on once chance and was denied one a one-timer by a great pad save from the Colorado netminder. Buffalo's final shot attempt missed the net as time expired.