It was the second of four meetings in the span of one month between the two rivals, with the Sabres having won the first matchup at KeyBank Center on March 5. Phil Housley pointed out afterward how the two games mirrored one another, but with opposite results.
In the first meeting, the Sabres received early goals from Sam Reinhart and Jason Pominville and were able to stave off the Maple Leafs' comeback attempt in a 5-3 win.
"It was a tale of two games," Housley said. "Last game we played them here, same thing happened, we got that two-goal lead. It was just a reversal tonight."
The Maple Leafs built their early lead on a pair of goals from James van Riemsdyk, who was less than 24 hours removed from scoring a hat trick in the team's shootout win over Dallas on Wednesday. Van Riemsdyk opened the scoring 3:39 into the contest with a bad-angle shot that beat Robin Lehner from behind the goal line.
As van Riemsdyk took his shot, Lehner got tied up with teammate Jacob Josefson and lost his stick.
"It's questionable goalie interference, I think," Lehner said. "I know it's not their guy, but their guy pushes him in. I have the post, I'm sitting there waiting, he rotates me out of position. Stuff like that happens."
Van Riemsdyk scored again three minutes later, this time with a well-placed shot from the edge of the left faceoff circle. With the Sabres shorthanded due to a delayed penalty, van Riemsdyk found space and had time to elevate a shot into the top corner of the net, above Lehner's glove.
"You could tell that we'd been off for a few days," alternate captain Jason Pominville said. "We didn't get the start, got behind the eight ball and were kind of chasing it after, never found a way to get back into it. Bottom line, we've got to have a better start and we've got to find a way to score 5-on-5, which we didn't do tonight."
Both of Buffalo's goals - from Reinhart and Pominville - came on the power play. After Reinhart brought the Sabres within one, the Maple Leafs extended their lead with goals from Connor Carrick and Tyler Bozak. Pominville's goal, scored with 59 seconds remaining in the second period, made it 4-2.
The Sabres continued their push in the third period, but Patrick Marleau capped the scoring for Toronto with 43.6 seconds remaining. Curtis McElhinney made 38 saves for the Maple Leafs.
"We did create looks, but we weren't able to score," Pominville said. "Usually if you don't score 5-on-5 you're probably not going to win a game."
The Sabres next meet the Maple Leafs at Air Canada Centre on March 26, capping a stretch of seven games in 12 days.
"We got these guys a couple more times, so we'll be ready," Beaulieu said.