The Sabres responded quickly -1:52 later - with a power-play goal of their own. Jack Eichel collected a pass from Rasmus Dahlin, skated down the left wing and feathered backhand pass through the slot to Reinhart, who knocked it in for his first goal of the preseason.
But with 4:25 left Adam Clendening was the benefactor of some quick passing in the Sabres zone that allowed them to slip around the Buffalo defense and get one by Wedgewood to tie the game once again.
Artemi Panarin gave Columbus the lead on the power play 6:31 into the third and they would not relinquish it. Buffalo almost answered back on the next shift, but Jake McCabe's shot hit the crossbar.
That chance was one of many for the line of Eichel, Reinhart and Jeff Skinner.
"We've had a lot of chances," Eichel said. "Even tonight, I had a few in front of the net. Skins had a couple, Reino the same. We're getting our chances. It's good. There's definitely some things I want to clean up. We can be a little cleaner on our possession in-zone.
"But we've only played together for five or so periods. It's important over the next week, we just keep working in practice. Make sure we're making the most of every rep we get together, try to build off what we've done and continue to build chemistry."
The line was assembled during Saturday night's preseason game against Toronto. It was Reinhart's first game since rejoining the team after signing a new contract, and while they didn't start the game together, they did enough good things (including a goal from Skinner) for Housley to want to see more. They practiced together on Monday and were out for the opening faceoff against Columbus.
"I liked the way we responded in the third after different circumstances went down," Reinhart said. "I liked our compete and we did start creating more."
Kevin Stenlund made it 4-2 with 11:05 left in regulation. Joonas Korpisalo played a strong game in the net for Columbus.