Nilsson had been outstanding in net to that point, making 41 saves and allowing just one goal in regulation in his first start since Oct. 29. That first goal came off the stick of Yohann Auvitu 3:13 into the third period on a high shot from the point that Nilsson saw late thanks to a net-front screen.
Nilsson thought he had played Greene's penalty shot well enough to make the save.
"I'm not trying to think about who's coming that much, I'm trying to read the play as it develops," Nilsson said. "Honestly, I thought I had him. I thought I had him covered and I thought I had it. But somehow it slipped through my pad."
The Sabres' loss on Friday night wasn't all that different from their loss by the same score to Ottawa on Wednesday. Both games saw the Sabres earn a first-period lead that they were unable to build upon thanks in part to an abundance of penalties.
Luckily, Buffalo's penalty kill was up to the challenge. Just as it had been against Ottawa, the penalty kill was tested by a long 5-on-3 in the second period and, once again, it was able to kill off the penalty successfully. The Sabres also killed off a double minor penalty for high-sticking assessed to Kane in the third.
The Sabres were 6-for-6 total on the penalty kill, improving their season mark at home to a perfect 17-for-17. For as successful as the penalty kill was, however, the amount of time spent shorthanded and the burden it placed on those killing the penalties threw the Sabres off after a 13-shot first period.
"It's tough when you run into penalties like that," forward Matt Moulson said. "They did a great job, but it really tires those guys out when you have that many."
Moulson scored Buffalo's only goal of the game in the first period, but they could have had more. Marcus Foligno, Zemgus Girgensons and William Carrier were among those who had grade-A scoring chances in front of the net in the first 20 minutes.
Instead, the Sabres were held to one goal or less for the third game in a row and the fifth time at home this season. They'll have a chance to steal one back from the Devils when they conclude their home-and-home set at Prudential Center on Saturday night.
"We've just got to find a way to score," Kane said. "That's our biggest area and biggest issue."