Trailing 1-0 in the second period, the Sabres gained the extra man after a roughing call against Scott Mayfield. Rather than serve as a springboard for the Sabres to tie the game, the ensuing power play led to three Islanders goals in a span of 1:47.
John Tavares scored the first shorthanded goal, which was his second goal of the game, after intercepting a Nathan Beaulieu pass in the Buffalo zone. Fifty seconds later, Casey Cizikas raced past Victor Antipin and scored to make it 3-1.
Josh Bailey scored 57 seconds after that, the end result of a 3-on-1 scoring opportunity while the Sabres attempted a change following the conclusion of their man advantage.
"A team like the Islanders, they have a good penalty kill and they put pressure on you," Sabres forward Evander Kane said. "As a guy who kills penalties, you put pressure on other teams to create turnovers, and especially when teams are doing certain breakouts, those turnovers can lead to scoring chances. We gave those up tonight."
Bailey's goal marked the end of the night for Robin Lehner, who finished with 12 saves on 16 shots in 27:00. Chad Johnson allowed one goal on 16 shots in relief.
"It's frustrating because I felt good today," Lehner said. "I felt encouraged going into the second period and I made some mistakes. I've got to come up with a save, Tavares got a breakaway and he beats me and then short after that Cizikas comes in and lets one rip. I feel like I have one but it finds the far corner … then we're on our heels."