That save was one of 43 the veteran Anderson made to lead the Senators to a 3-1 victory. The Sabres outshot the Senators, 44-29, with 19 of those shots coming in the final 20 minutes, yet their only goal came on a feed from Rodrigues to Zemgus Girgensons in the second period.
Jean-Gabriel Pageau scored twice for the Senators, including the game-winner at 5:16 of the third period. Brady Tkachuk buried an empty-netter to complete a three-point night, which included the primary assists on both Pageau goals.
The Sabres entered the contest looking to build on their 3-2 victory at home over Los Angeles on Saturday. They began the night with good stretches of possession in the Senators zone, though coach Ralph Krueger felt they initially lacked the net-front presence to capitalize.
"The 25 scoring chances and the 44 shots speak for themselves," Krueger said. "I think Anderson had a world-class game today and we had good control early in the game, but we weren't creating the net pressure we should have out of the puck control we had, and they were opportunistic on their chances."
Pageau opened the scoring with 53.2 seconds remaining in the first period, burying a one-timer fed by Tkachuk from the corner. The Sabres began to attack the net more in the second, eventually connecting on Girgensons' deflection from the slot.
According to NaturalStatTrick.com, high-danger attempts at 5-on-5 during the second and third periods were in Buffalo's favor by a tally of 10-3. With Anderson in net, it didn't matter.
Before his blocker save in the third, Anderson delivered a poke check to stifle Rodrigues on a power play in the second. When the Sabres got bodies in front, Anderson evaded the traffic and swallowed shots without allowing second chances.
"I thought we went really a long stretch there without giving up any big chances," Krueger said. "In the end, it's failed opportunity. We just didn't use the opportunities we created and we had. Anderson was as good as it gets, and we just need to regroup.
"Our goal as a team is to be in every game as much as we can. We were definitely in this one, and we have to take the good things with us, and we have to believe that more often than not we win a game like today."
Linus Ullmark was strong in his own right throughout a 27-save performance. He stopped a Connor Brown breakaway in the first period and robbed Tyler Ennis with his pad on a power play in the second.