The Sabres (4-7-2) are coming off a 5-4 win at Arizona Thursday. Benoit Pouliot tallied two goals and one assist as the Sabres built a 5-1 lead and then held on as the Coyotes rattled off three goals in the last half of the third period to win for the first time in three games.
"We got away from what made us successful, and we almost shot ourselves in the foot," Sabres coach Phil Housley said. "Obviously, we'll take the win."
Buffalo defenseman Justin Faulk played his first game of the season after missing the first 12 with a lower-body injury.
Saturday's game is the final of a two-game road trip for Buffalo which is 3-2-0 in its past five games overall.
Injuries:Justin Bailey (lower body) is day to day. D Nathan Beaulieu (upper body), D Josh Gorges (lower body), F Jacob Josefson (lower body), D Zach Bogosian (lower body), and F Evan Rodrigues (hand) all are on injured reserve.