Marc-Andre Fleury started for Pittsburgh and made 31 saves in a 3-1 win. Tristan Jarry, who didn't skate in warmups, was Fleury's backup.
"The fact that we have [Fleury] and Matt I think gives us a comfort level because we know they're both No. 1 goalies," Penguins coach Mike Sullivan said. "I've said to these guys all along, 'We're going to need both of you.' It's just the way the game is, today's game. We've certainly used both of them all year long, they've both helped us win, and we have a comfort level with either guy in the net."
Fleury, who played 38 games in the regular season, said he saw Murray leave warmups early because of the injury. He was told by goalie coach Mike Bales while walking back to the locker room that he was going to start.
"I just tried to approach it as a regular game," Fleury said. "I was a little nervous at the beginning, maybe from not expecting it, but the guys did a great job in front of me all game long blocking shots and taking rebounds away. At the end, it was a great feeling."
Fleury tied Tom Barrasso for the Penguins record with his 101st game in the Stanley Cup Playoffs; Fleury has won 54.
Game 2 in the best-of-7 series is Friday at PPG Paints Arena (7 p.m. ET; NHLN, SN, TVA Sports 2, ROOT, FS-O).