The forward, who has not played since Feb. 8, has 45 points (16 goals, 29 assists) in 56 games. The Canucks originally said he would be out three weeks, but general manager Jim Benning said Tuesday that prognosis has worsened.
"It looks like it's going to be more severe than what we originally thought," Benning said. "It looks like he could be done for the year."
Benning said Vancouver's decision to acquire forward Tyler Toffoli in a trade with the Los Angeles Kings on Monday was directly related to Boeser's injury.
"It's an eight-week injury," Benning said, "so we wanted to make sure that ... we had ourselves covered. Our players have worked hard this year, our coaches have worked hard, for fans we want to stay in the race here coming down the stretch, and so we felt like this was something we could do now."
The Canucks (32-22-5), who trail the Edmonton Oilers and Vegas Golden Knights by one point for first place in the Pacific Division, host the Minnesota Wild on Wednesday (10:30 p.m. ET; ESPN+, SNP, FS-N, FS,WI, NHL.TV).
Forwards Micheal Ferland and Josh Leivo are out for the the season. Ferland has not played in the NHL since Dec. 10 because of recurring concussion-like symptoms, and Leivo has not played since Dec. 19 because of a fractured kneecap.
"I feel for [Ferland], he's worked hard and wants to get back playing," Vancouver coach Travis Green said after practice Saturday. "You just feel for a guy when he works that hard. As far as a coach and a player you feel for him.
"You want him to get back as soon as he can; never mind the team aspect, but from the personal aspect of him being a guy that loves the game and loves to play it, it's hard when you're injured. And when you work that hard to get back and don't, it's difficult."