Turgeon was the first overall selection of the 1987 NHL Entry Draft, chosen by the Buffalo Sabres. He joined the NHL squad that fall and contributed to the Sabres reaching the playoffs for the first time in three seasons. During his sophomore season, Pierre truly revealed that the team's expectations of him were warranted, as he led Buffalo in scoring with 34 goals and 88 points through the regular season. He enjoyed an outstanding season in 1989-90, notching 40 goals and 66 assists for 106 points, good for seventh-place in NHL scoring that season, and earned him a spot in the 1990 NHL All-Star Game. After another 30+ goal season in 1990-91, Turgeon was traded to the New York Islanders early in the 1991-92 season, packaged with Benoit Hogue, Uwe Krupp and Dave McLlwain in exchange for Pat LaFontaine, Randy Hillier and Randy Wood. His best season on Long Island came in 1992-93 when he earned career-highs in goals (58) and points (132), tied for fifth-best in the league. He again was named to play in the NHL All-Star Game that season. Pierre's post-season was interrupted that spring when he was hit from behind during a goal celebration. Dale Hunter of the Washington Capitals earned a 21-game suspension for his transgression. Turgeon was able to return from a separated shoulder after missing seven playoff games. During the post-season award ceremony, Pierre was named recipient of the Lady Byng Memorial Trophy for his gentlemanly play.