Gabriel Bourque and Nail Yakupov tallied the first two markers for Colorado, and Blake Comeau recorded the game-winner with 7:43 left in regulation.
The Avalanche's top line got on the scoresheet late when Gabriel Landeskog recorded an empty-net goal in the final minute of play.
"Those guys have carried the load offensively for a huge part of this season. They've been outstanding," Comeau said of the Avs line of MacKinnon, Landeskog and Mikko Rantanen. "They're a big reason why we are where we are. With that being said, we've had a lot of things happen throughout this streak that we're on to give us success. Great penalty kill, great goaltending, our defense has played outstanding. We've had contributions from every line at key moments in the game. And even if lines aren't scoring, they've done a good job of committing defensively. We've found a way to lock things down. We're playing great defensive hockey. Defense first, and that is translating for chances for us."
Comeau's ninth goal of the season came from a deflection off a shot from Carl Soderberg to give the Avalanche back the lead after trailing for the first time since its last defeat on Dec. 27 versus the Arizona Coyotes.
"I knew we had a quick 3-on-2, passed it over to Carl, and I thought I saw the defenseman pull up and maybe cheat a little bit," Comeau said. "I tried to drive hard to the net, and Carl made a great play by throwing it there. Definitely happy to see it go in."