The Red Wings finished the contest with four straight goals and the Avalanche lost 5-1 in the team's final contest at Joe Louis Arena.
"I thought we outplayed them for most of the game, but that's just how our season's going. So it's tough," said forward Nathan MacKinnon, who recorded Colorado's only tally.
The official scorers registered four giveaways from the Avs in the third period, and most of those led to the puck in the back of their net.
"They end up getting three rush-goals in the third period and the power play," said head coach Jared Bednar. "So obviously not a great finish. We have to be much better than that, but I liked our game up until that point."
Colorado finished with a 24-23 edge in shots on goal and a 48-40 advantage in attempted shots. However, only MacKinnon's redirection of the puck off his skate at 3:44 of the third got past goaltender Jimmy Howard.
"We got a big goal there at the start, and then I wasn't good enough," said Avs goaltender Calvin Pickard. "Obviously, that was a big, painful third period. Once they got one then they started feeling it, and we just had no answer for it."
Tomas Tatar led the way for the Wings as he scored back-to-back goals in a 1:36 span to give Detroit a lead it wouldn't relinquish.
"It's a frustrating loss because we have a chance to scratch and claw our way back into that (game), and we stayed with our game the whole time until that point," Bednar said.
This was the second meeting in four days between these once Western Conference rivals, with Colorado winning the first outing 3-1 on Wednesday in Pepsi Center.
The Avs knew what they were facing when it came to the speed that some of the Red Wings' younger players possess. But unlike three days earlier, Colorado couldn't contain it and the club got burned because of it.
"We saw that in our game the other night at home, and we wanted to make sure we were grinding them down a little bit in the offensive zone and putting pucks in behind them," Bednar said. "When you think about it, that's how they got us tonight, the rush chances and the rush-goals against. Part of that was caused by them coming at us, part of it was our puck decisions and a couple soft plays in the middle of the ice."