The Blackhawks had an apparent power-play goal by Teuvo Teravainen at 12:15 ruled out for offside by video review.
Filip Forsberg brought the Predators to within 2-1 at 13:41 when he split Chicago defensemen Allan and TJ Brodie in the slot and moved in on Mrazek.
Nyquist's short-handed goal at 16:59 tied the game. Nyquist skated into the offensive zone and put a wrist shot past Mrazek.
“It was obviously a big swing,” Forsberg said of the disallowed Chicago goal followed by the Nashville comeback. “That’s why we’ve got the video crew back here working their butts off for us. Best crew in the league. That was a great call. They saved us there.”
The Blackhawks said they felt the momentum shift after that sequence.
“Yeah it shifted, but I don't know if that was the reason (for the loss),” said defenseman Connor Murphy. “There were just lapses. We lost our momentum and our jump. That's lulls in the games. That'll happen, and unfortunately we let it slip too far away.
“You're always frustrated if it doesn't go in, but I don't think that's a reason guys are deflated and thinking it's going to affect them the next shift.”