Avalanche forward Nazem Kadri collided with Binnington with 13:15 remaining in the first period.
After the game, Blues Head Coach Craig Berube said Binnington was undergoing evaluation for a lower-body injury.
Berube said the team would recall a goaltender if needed.
"It's always tough. Binner is a heart and soul (player), playing unbelievable," Blues captain Ryan O'Reilly said of the play. "It took the momentum away... Things like that happen, we're a good team and we could have done a better job of getting momentum back."
Through six playoff appearances this season, Binnington is 4-1 with a 1.75 goals-against average and a .948 save-percentage.
