Perron - who had 55 points (17 goals, 38 assists) in 55 games this season prior to Thursday's regular-season finale - recorded two goals and an assist in a 7-3 win against the Minnesota Wild to record his 58th point in his 56th game.
The last Blues player to accomplish the feat was Pavol Demitra, who recorded 93 points in 78 games during the 2002-03 season.
"It's nice, it's been in the back of my head for a bit," Perron said of the stat. "After a certain amount of games, you don't know how long you can sustain that (pace)… It's definitely pretty cool, and hearing what (Darren Pang) said about Pavol Demitra, it's cool."
In 906 career NHL regular-season games, Perron has 241 goals and 366 assists (607 points).