Pietrangelo passed Al MacInnis (325) for the franchise lead and moved into sole possession of fourth overall amongst all Blues skaters.
"It's good company. Those guys had pretty good careers," Pietrangelo said after the game. "It's always nice to have some accomplishment, it feels pretty cool."
MacInnis still holds the franchise lead in points by a defensemen with 452. Pietrangelo ranks second in that category with 429 points.
Sunday's game was also Pietrangelo's 728th career game, which moves him ahead of David Backes for sixth among skaters on the Blues' all-time games played list.