Pietrangelo is expected to play in his 600th career game Wednesday when the Blues host the Detroit Red Wings at Scottrade Center (7 p.m., NBCSN, KMOX).
After Wednesday, the 28-year-old defenseman will sit just 13 games behind Al MacInnis (613) for fourth.
Through 599 games, Pietrangelo has recored 75 goals, 266 assists (341 points) and a plus-62 rating.