"He's played well," Berube said of Kyrou. "He's had a good start to the season, he's a very highly-skilled player and does a lot of good things with the puck. (I'm) just trying to put the lines together with a little bit of depth and spread it out a little bit."
In addition to Barbashev, the Blues will be without Jaden Schwartz (lower-body), Robert Thomas (wrist), Tyler Bozak (upper-body), Colton Parayko (undisclosed) and Vladimir Tarasenko (shoulder).
Blues captain Ryan O'Reilly said he can't remember a time in his career when so many key teammates were injured.
"It's pretty crazy to see," O'Reilly said. "I still think we're a very good hockey team with depth, guys coming in with their presence, physicality and work ethic - it's good. We're still a great team. There are a lot of unfortunate injuries though, it's tough. The big guys in the lineup, for sure, we have to be the difference. We have to create, get the puck to the net, find ways to outperform or outwork the team we're playing. It's a difficult challenge but your best players have got to be your best players in order to win. That's how it is."
