Brayden Schenn (upper-body) and Marco Scandella (lower-body) will both be out.
Ville Husso will start in goal.
"One more game and then the fun part starts," Husso said. "We just need to finish strong and get a win tonight, get ready for playoffs."
The Blues can still secure home-ice advantage in the first round of the Stanley Cup Playoffs with a win against the Golden Knights AND a Colorado Avalanche regulation victory over the Minnesota Wild on Friday.
"We don't know the outcomes of the other games," Berube said. "We've got to focus on what we can control, and that's the way we play (tonight) and that's it."
The Blues held an optional morning skate before Friday's matchup with Vegas. The projected lineup below is based on Thursday's team practice and assumes Tyler Bozak will take Schenn's spot on the third line. If that changes, the lineup below will be updated at pregame warm-ups.