Schenn, who missed nine games with an upper-body injury, will be playing his first game since Nov. 4 in San Jose.
"I've said time and time again, he's an emotional leader for us," said defenseman Torey Krug. "We miss his physicality, his scoring touch. He does everything for us, he's a jack of all trades. To have him back in the lineup, it's a big step for our group and our consistency down the middle. Our team got better today by putting him in the lineup."
Through nine games this season, Schenn has three goals and three assists (six points).
Schenn's return means the Blues will have a fully healthy roster for the first time this season.