But it's what happened in between and after those Domi goals that sunk the Canadiens and handed them just their second regulation loss of the season.
After a stellar first period in which they led for all but the first 77 seconds, the Sabres adjusted their game and tied things up twice to emerge with a 2-2 tie heading into the final frame.
"That's a hungry team over there. We were coming in, and they showed it," lamented Domi, whose first three goals of the season have come in the first four minutes of the games in which they were scored. "There's some stuff we need to clean up and we'll address that as a group, learn from it, and move on. Overall, it's a tough loss, and we could've been a lot better."
That said, when it was suggested to him that the Habs may have run out of gas in the third after the Sabres started winning battles to pucks and along the boards, Domi was adamant that wasn't the case.
"No, not at all," he stated bluntly. "We just have to find a way to win.
"Sometimes, execution is not quite where it usually is or where it needs to be. It's a good test for our group. We know we can bounce back from this. You're not going to win every game in an 82-game season. We're learning how to lose and come back from it."
Head coach Claude Julien agreed, saying that the Sabres won a "battle of wills", but noted that both Domi and goaltender Antti Niemi stood out with excellent efforts in Buffalo.
Niemi didn't allow a goal until the 21st shot he faced and finished with 38 stops on the night, which did not go unnoticed by his boss.
"He was excellent for us tonight. He kept us in the game by making some big saves when we needed them," Julien said of Niemi, who was looking for his third win of the season. "There's no doubt that he did his job."
Despite all the positives, the Canadiens faced some adversity when they came up on the short end of a coach's challenge after they pleaded goaltender interference on Jason Pominville's second goal, and when they allowed a pair of Sabres power play goals - including Kyle Okposo's game-winner on a late tripping call to Joel Armia that Julien described as "tough to digest".
But Domi, who now leads Montreal with 10 points, believes the Canadiens showed some positive strides even if they weren't able to finish the job, and is confident they will come out better as they attempt to return home with points on the board after another crucial divisional game coming up on Saturday.
"We're going to play against a good team in Boston, a good veteran team," he said. "We're going to have to be a little more sharp.
"That's the next test: we can't lose two in a row," concluded Domi. "We have to be better next game, and we will be."