The loss dropped Anaheim to 30-35-14 (74 points), seventh in the Pacific Division, with three games remaining on the regular-season schedule. The Ducks will return home tomorrow for the final NHL game of Getzlaf's career on Fan Appreciation Night at Honda Center.
Zegras scored his 22nd goal of the season, passing Bobby Ryan for the Ducks all-time rookie single-season scoring record (58 points). Zegras is second among NHL rookies in points, third in assists (36) and fourth in goals (22).
Anthony Stolarz was strong throughout his 22nd start, stopping 36-of-39 shots and keeping the Ducks in it early with a terrific first period.
Gerry Mayhew also scored for Anaheim and now has three points in his last three games (2-1=3).
With the win, the Kings improved to 43-27-10 (96 points) and inched closer to clinching a postseason berth.
Jonathan Quick made 19 saves for his 27th career win over the Ducks, his second of the week. Quick has made six straight starts in net for LA, seemingly taking hold of the crease heading into the playoffs. Arthur Kaliyev, Matt Roy, Alexander Edler and Alex Iafallo scored for the Kings.
LA went ahead first midway through the opening frame when Kaliyev slammed home a backdoor pass from former second-overall pick Quinton Byfield.
Anaheim then responded early in the second on Zegras' record-setting point courtesy of a classic Getzlaf power-play cross-seam pass. The Ducks captain held the puck in the left faceoff circle, surveying his options before delivering a dart across the ice to Zegras, who snapped a wrist shot over Quick's glove to level the score.