The Bolts got on the board at 5:48 of the period with Tyler Johnson finishing off a two-on-one feed from Ondrej Palat. Steven Stamkos then capped off a furious push by the Lightning with a one-timed goal from the left circle just as a power play expired.
Erik Cernak scored the game-winner early in the third with a shot from the point. The Lightning won the faceoff back to Cernak who beat Jonathan Quick through a screen in front.
Stamkos added an empty net goal with less than a second remaining in regulation to round out the scoring.
The road trip continues on Friday night as the Bolts face the Ducks in Anaheim.
Scoring Summary
1st Period
LAK | 6:44 Tyler Toffoli (13) - Adrian Kempe, Anze Kopitar - PPG
2nd Period
LAK | 1:18 Alex Iafallo (11) - Dustin Brown, Alec Martinez
TBL | 5:48 Tyler Johnson (12) - Ondrej Palat, Anthony Cirelli
TBL | 11:58 Steven Stamkos (21) - Nikita Kucherov, Brayden Point
3rd Period
TBL | 4:13 Erik Cernak (4) - Nikita Kucherov, Steven Stamkos
TBL | 19:59 Steven Stamkos (22) - Brayden Point, Alex Killorn - EN