Vegas plays St. Louis twice this week, at T-Mobile Arena on Tuesday (9 p.m. ET; ESPN+, ATTSN-RM, FS-MW, NHL.TV) and Thursday (9 p.m. ET; ESPN+, ATTSN-RM, FS-MW, NHL.TV).
The teams play eight times this season in the Honda West Division, with the NHL realigned temporarily and playing an intra-division schedule due to Canada-United States border restrictions and the need to reduce travel amid the coronavirus pandemic.
Won't it be extra weird?
Pietrangelo said he and his wife, Jayne, talked about it Monday.
"I think if it was my first game here, maybe it would be a little bit different," Pietrangelo said. "We've played six games now. I mean, I'm kind of past that point. I knew this day would come eventually. I've been joking that, I guess, if you're going to do it, just do it eight times in one year and get past it.
"So no, I feel good. I feel comfortable about it and ready to kind of get it over with so we can move forward."
Pietrangelo has strong ties to St. Louis.
The Blues selected him No. 4 in the 2008 NHL Draft, and he played 12 seasons with them, becoming the first player in their history to hoist the Stanley Cup when he did it as captain in 2019. He ranks fifth in games (758), third in assists (341) and ninth in points (450) on their all-time list.