Quinton Byfield, the No. 2 pick in the 2020 NHL Draft, made his NHL debut for the Kings. The 18-year-old center had four shots on goal and won 8-of-12 face-offs in 17:21 of ice time.
"I knew I had a lot of support behind me tonight, just wanted to go into the game with confidence," Byfield said. "You try to step up your game and bury all your chances. It was a lot of fun having fans in there and when you make a play or do something, make a good play or make a good pass, get a shot, the fans, you could hear them and it definitely gave me confidence out there."
Kings coach Todd McLellan said, "Overall, definitely a passing grade for him. He was probably one of our better players. We had some guys that we certainly count on night in and night out that didn't have very good nights tonight so it's something they need to fix."
The Ducks (15-28-7) were eliminated from Stanley Cup Playoffs contention when the St. Louis Blues defeated the Minnesota Wild 4-3 on Wednesday. John Gibson made 28 saves.
Cal Petersen made 19 saves for the Kings (18-23-6), who have not won consecutive games since a six-game winning streak Feb. 11-24.
Los Angeles is seventh in the eight-team Honda West Division, eight points behind the fourth-place St. Louis Blues for the final Stanley Cup Playoff berth. The Vegas Golden Knights, Colorado Avalanche and Minnesota Wild have qualified from the division.
The teams continue their four-game set in Anaheim on Friday.
Fowler cut around Andreas Athanasiou with a toe-drag and scored on a wrist shot from the slot at 18:59.
"I mean, that's not a move that I would be doing, but he can pull that off so that was a nice move by him," said Ducks defenseman Simon Benoit, who made his NHL debut.
Gabriel Vilardi put the Kings up 1-0 at 4:50 of the second period on the power play. Adrian Kempe's shot from the point was saved by Gibson, but Trevor Moore kept the rebound alive to set up Vilardi with a shot into an open net from outside the crease.