The No. 20 pick in the 2013 NHL Draft, Mantha has 158 points (80 goals, 78 assists) in 242 games through five seasons with Detroit.
The Red Wings are averaging 2.27 goals per game this season, last in the NHL, and have scored 59 goals this season, tied for second-fewest.
"When one of the players leading our team is injured, obviously it [stinks]," forward Andreas Athanasiou said, "but injuries happen and being good buddies with him it [stinks] to see him when you come in the morning and look for him and he's doing stuff for his knee and stuff.
"It's never fun seeing someone injured, but at the same time, injuries happen and a lot of guys have to step up."
Detroit (7-16-3), winless in its past six games (0-4-2), host the Toronto Maple Leafs at Little Caesars Arena on Wednesday (7 p.m. ET; SN1, SNE, SNO, FS-D, NHL.TV).