Werenski made it 6-1 at 4:33 of the third period on the power play.
Domi's goal at 8:48 made it 7-1. Cole Sillinger, the No. 12 pick in the 2021 NHL Draft, got an assist in his NHL debut.
"It took me a couple of shifts to realize I was playing in the NHL but after that as the game got on, I got more comfortable," Sillinger said.
Clayton Keller scored at 16:46 on the power play at 16:46 to make it 7-2.
"We've got 81 more games to go so onto the next one," Keller said. "You learn from it. It's a long season and move on from it."
Gustav Nyquist made it 8-2 at 18:36.
NOTES: This was the 11th time coaches have made their NHL debuts against each other, the most recent being Randy Carlyle of the Mighty Ducks of Anaheim and Trent Yawney of the Chicago Blackhawks on Oct. 5, 2005. … Sillinger is the son of former Blue Jackets forward Mike Sillinger. … The Blue Jackets placed forward Emil Bemstrom on injured reserve with a left oblique strain. He is expected to miss four to six weeks. … Blue Jackets forward Gregory Hofmann also made his NHL debut, playing 16:48. … Shayne Gostisbehere had an assist in his Coyotes debut.