Wedgewood made 13 saves in the third period when Arizona was outshot 13-3.
"It's been tough, there's been some frustration," Wedgewood said. "I hope I've given the guys a little bit of spark. This was a gutsy win."
NOTES: The Coyotes were missing nine players, seven due to injury, including defenseman Anton Stralman, who was a late scratch with a lower-body injury, and forwards Andrew Ladd and Johan Larsson in COVID-19 protocol. ... Arizona scored multiple power-play goals in a game (2-for-2) for the first time this season. It was 30th in the NHL at 12.5 percent (5-for-40). ... Kyrou has scored seven points (five goals, two assists) during his point streak. ... Blues center Oskar Sundqvist played 9:45 in his first game since March 19 following a torn left ACL and hip surgeries. ... Blues defenseman Scott Perunovich played 18:26 in his NHL debut. He had one shot on goal, and played 2:59 on the power play. … O'Reilly has played 871 NHL games for the Blues, Buffalo Sabres and Colorado Avalanche. He has 133 assists in 220 games with St. Louis. … Arizona's season start with one win was the longest since the Florida Panthers needed 16 games to win two in 2000-01 (2-7-3 with 4 ties). The Winnipeg Jets needed a record 34 games to win two games in 1980-81 (2-25-7 ties).