The final two goals were the difference in a 5-3 Blackhawks win.
"That was a big goal," Blackhawks coach Joel Quenneville said of the tiebreaker. "He scored earlier on another big one. That line [with Patrick Kane and Artem Anisimov] was just ordinary, but in a game like that they still find ways to contribute meaningful goals, meaningful plays and high-end play recognition to go along with it."
Panarin has 22 goals this season. He is the first Blackhawks rookie to score a hat trick since Tyler Arnason on Dec 28, 2002, at the San Jose Sharks, and the first to be the first to 20 goals since Eric Daze in 1995-96, according to the Elias Sports Bureau.
"He wants to score, and when he finally gets a few here tonight, he plays with so much more confidence and energy," Chicago captain Jonathan Toews said. "When he goes out there, things happen every single shift. You saw that again tonight."
Dylan Larkin of the Detroit Red Wings is second among rookies with 18 goals; Jack Eichel and Sam Reinhart of the Buffalo Sabres each has 17.