Matthews missed 10 games from Feb. 24-March 20 last season because of a shoulder injury.
"No, it's not the same shoulder, it's not," Babcock said. "He did his work this summer to get way stronger, built muscle around his shoulders, wants to protect himself. Sometimes things happen."
Maple Leafs center Nazem Kadri said it would be difficult to replace Matthews if he misses any length of time, but he feels Toronto has the depth to make due in his absence. Last season, the Maple Leafs went 11-7-2 without Matthews.
"He's just a one-of-a-kind player, it's hard to fill that void, but I don't think we rely on one specific guy," Kadri said. "We've been talking about depth for 10 months here with this group, and this is the time where it really showed, especially down the stretch in this game. It was just a resilient win. We always believed. We had a couple guys step up, [Frederik Andersen] shut the door and we were able to capitalize."
Matthews had three shots on goal in 7:38. He does not have a point in his past four games after starting the season with seven consecutive multipoint games.
Matthews' 10 goals are tied for second in the NHL with Filip Forsberg of the Nashville Predators, Gabriel Landeskog of the Colorado Avalanche and David Pastrnak of the Boston Bruins behind Chicago Blackhawks forward Patrick Kane's 11. Matthews has 16 points (10 goals, six assists) in 11 games.
"It's tough to lose one of your best players, but you just have to keep playing and move on," Maple Leafs defenseman Jake Gardiner said. "I'm hoping he's OK, thinking that in the back of your head but just got to keep playing the game."