Matthews leads Toronto in scoring with 50 points (28 goals, 22 assists) in 53 games. The 20-year-old won the Calder Trophy as NHL rookie of the year last season with 69 points (40 goals, 29 assists) after the Maple Leafs selected him with the No. 1 pick in the 2016 NHL Draft.
Matthews has missed 10 games this season because of injuries. On Nov. 8, he sustained an upper-body injury and missed four games. On Dec. 9, Matthews collided with teammate Morgan Rielly in a game against the Pittsburgh Penguins and missed the next six games with a concussion.
"I think it's a real opportunity [for other players]," Babcock said. "Auston's going to be out, for a bit anyway, so there's an opportunity for [center William Nylander] or [center Patrick] Marleau or whoever is going to play in the middle. And then someone else will get an opportunity. And if not, we've got more guys on the Marlies (of the American Hockey League) who are looking for an opportunity."
Toronto (38-20-5) is in third place in the Atlantic Division, one point behind the second-place Boston Bruins, who have five games in hand. The Maple Leafs host the Bruins on Saturday (7 p.m. ET; SN, NESN, NHL.TV).