Marchand had a goal and an assist to become the 10th player in Bruins history with a 100-point season (36 goals, 64 assists). It is the most points by a Boston player since Joe Thornton had 101 in 2002-03.
"It's a cool personal stat, but it all goes toward the same goal to get to the playoffs and we're right there," Marchand said.
Jake DeBrusk had two goals and an assist, and Tuukka Rask made 32 saves for Boston, which led 5-0 early in the third period.
"They were playing for a purpose," Blue Jackets coach John Tortorella said. "They were playing for something. They played better than we did."
Columbus had outscored opponents 24-4 during a five-game winning streak.
Blue Jackets goalie Sergei Bobrovsky was pulled at 16:00 of the second period after allowing four goals on 23 shots. Joonas Korpisalo allowed two goals on five shots.
DeBrusk made it 1-0 at 1:58 of the first period when his deflection of a David Krejci pass went high over the goal, bounced off the top of the net and went off Bobrovsky's back and in.
"Just some puck luck, I'm not sure," DeBrusk said.
Marcus Johansson made it 2-0 at 17:27 of the first, scoring on a rebound after Bobrovsky made a left pad save on a shot from the slot by Charlie Coyle.