Jimmy Howard made 31 saves, and Tyler Bertuzzi had three assists.
"I think the thing that should encourage our fans is that this run is being led by our young core of players who are going to be here for a while," Blashill said. "You've got Mantha, Bertuzzi and [Dylan Larkin] on the first line, and look what they did against Patrice Bergeron's line. And then you've got [Andreas Athanasiou] going against David Krejci's line."
Mantha gave the Red Wings a 1-0 lead at 10:26 of the first period on a one-timer off a cross-ice backhand pass from Larkin. He made it 2-0 with one second left in the period on a one-timer from the high slot on a power play.
Jake DeBrusk cut it to 2-1 at 2:01 of the second period after taking a pass while alone in the slot from Krejci.
Brad Marchand tied it 2-2 at 9:50, finishing off a 2-on-1 with Bergeron. The goal was Marchand's 26th while shorthanded in the NHL, passing Rick Middleton for the most in Bruins history.
"It's a great record to have, but setting it doesn't mean as much when you don't win," Marchand said. "It is hard to be happy when we all know we aren't playing well."
David Backes gave Boston a 3-2 lead at 19:00 when he redirected Kevan Miller's point shot past Howard.
Mantha completed the hat trick to tie it 3-3 at 1:17 of the third period with a power-play goal off a cross-crease pass from Bertuzzi.
"I just got my first hat trick earlier this season (Jan. 12 against the Minnesota Wild), so I know how special it is," Bertuzzi said. "When we went out there for the power play, I told [Mantha] I was going to get him the puck in that spot."
Hirose, playing his seventh NHL game, scored eight seconds later off a pass from Athanasiou to give Detroit a 4-3 lead.
"It's a great feeling," Hirose said. "I know when Andreas has the puck, everyone on the ice is watching him, so I just tried to find a spot where I could take a pass and get off a good shot."
Filip Hronek extended the lead to 5-3 at 12:03, and Larkin added an empty-net goal with 58 seconds remaining for the 6-3 final.