The 22-year-old undrafted forward had 25 points (10 goals, 15 assists) in 25 games for Penn State University as captain during his senior season. He helped the Nittany Lions go 20-10-4, including 12-8-4 in the Big Ten this season.
"Brandon will bring a combination of skill, hockey sense and character to our organization," Sabres general manager Jason Botterill said. "We're confident that his four years at Penn State with coach Guy Gadowsky have prepared him well for the next phase of his development."
Biro attended Sabres development camp in June 2018 and said he felt like he belonged.
"You were just treated like a professional even though I was an undrafted free agent who didn't really have any ties to the organization," Biro told the Sabres website Wednesday. "Just the way they treated everyone was awesome. It was something I wanted to be a part of."
Biro leaves Penn State ranked in its top 10 with 41 goals (tied for eighth), 75 assists (third) and 116 points (fourth). He won the Big Ten championship as a freshman in 2016-17 and was a conference all-star honorable mention with NCAA career highs of 16 goals, 24 assists and 40 points as a junior in 2018-19.
